Jiangyin Snynxn Granulating Drying Equipment Co., Ltd.

Specializing in the production of pharmaceutical machinery and granulating drying equipment

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Granulating

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Fluid Granulation

Fluid bed spray agglomeration is also often in colloquial terms refered to as fluid bed granulation. Powders are fluidized and a binder solution or suspension is sprayed onto the fluidized particles, creating liquid bridge which form agglomerates from the powder. As soon as the desired size of the agglomerates is achieved, spraying binder is stopped and the liquid inside of granule is evaporated and exhausted by fan. The structures created by the liquid bridge are then maintained by solid binder. Whatever has been liquid inside the agglomerates is now void, as such permitting modified size and porosity of the agglomerates for their intended function, e.g. for compression into tablet or fast dissolving instant drink applications. The lack of kinetic energy in the agglomeration zone results in light structures with plenty of internal capillaries. The usual size range found on the market is approximately 0.2 to 2.5 mm.

 

Typical features of fluid granulation
• dust free
• free flowing
• highly dispersible
• excellent solubility
• easily compressible
• low bulk density
• adjustable porosity

 

Equipment Model: FL FLUID-BED GRANULATOR

 

 

Spray Granulation

Fluid bed spray granulation produces dense particles by layering solids from a suspension, solution or melt onto nuclei created as a spray-dried by-product of the atomized spray liquid or abrasion from larger particles or on starter nuclei inserted as a defined quantity. For this processing option the liquid only serves as a vehicle for the solid particles contained in the spray liquid.

This process would be rather lengthy in a batch type fluid bed, unless process ramps are introduced:
• Produce spray-dried powders by spraying the liquid at a high temperature
• Agglomerate the powders by means of the agglomeration technique
• Layer the majority of the liquid on the such produced nuclei
With this processing technique the usual finished particle size can range from 0.2 – 5.0 mm.

 

Typical product features
• Dust free
• High spherocity
• Free flowing
• Easily dispersible
• Good solubility
• High density
• Low hydroscopicity
• Smoot surface
• Low abrasion
• Narrow particle size distribution

 

Equipment Model: PGL-B SPRAYING DRYER GRANULATOR

 

 

High Shear Granulation

High shear agglomeration by means of bottom driven mixing blades in a closed container has been a popular processing option for the pharmaceutical industry, whereas the food, feed and chemical industries. The impact of the rotating impellers or blades form denser agglomerations than with the fluid bed process. Compared to the latter, particle size is usually wider with the mechanical impact often enabling a reduced quantity of the required binder, which is either poured onto the powder or sprayed by an air atomized nozzle. The latter allows a more uniform dosing of the binder liquid.

 

Typical product features
• Dust free
• Free flowing
• Good dispersibility
• Good solubility
• Easily compressible
• Compact structure
• Low hygroscopicity
• High bulk density

 

Equipment Model: GHL HIGH-SPEED MIXING GRANULATOR

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